Sr. Mgr, Internal Supply Chain

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Job description

Attention recruitment agencies: All agency inquiries are vetted through 4DMT's internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.

Company Differentiators:

• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine

GENERAL SUMMARY:

The Senior Manager, Internal Supply Chain Operations, will report directly to the Director of Supply Chain and will be responsible for overseeing all facets of internal supply chain activities. This includes procurement, inventory management, logistics, and warehousing to support internal manufacturing processes. The role ensures that these supply chain functions are carried out efficiently, cost-effectively, and in alignment with the company's overall objectives. The Senior Manager will lead a team of supply chain professionals and collaborate closely with departments such as Quality, IT, Facilities, Finance, Process Development, and Manufacturing to maintain seamless operations and high customer satisfaction, as detailed in the Responsibilities section. This position requires full-time on-site presence, with occasional visits to offsite warehouses and supplier locations. Additionally, the role may involve occasional travel for supplier meetings, logistics coordination, or industry conferences.

RESPONSIBILITIES:

Technical: 60% of TIME

• Identify and implement opportunities for process improvements and best practices in supply chain operations, particularly in materials management.
• Identify and lead cross-functional initiatives to enhance the efficiency and effectiveness of supply chain processes.
• Accountable for raw materials testing, and release, including testing lab oversight
• Work with Manufacturing and Process Development teams on streamlining initiatives and reduce waste by planning around material expiry
• Work with Manufacturing and Process Development to support non-GMP engineering runs and other development activities
• Monitor and analyze key performance indicators (KPIs) to pinpoint areas for improvement, implementing corrective actions as needed.
• Oversee the procurement process, ensuring timely and cost-effective acquisition of materials and services per pre-established budget plan.
• Overseeing warehouse operations across various locations and coordinate logistics between sites.
• Implement inventory control policies and procedures to reduce excess and obsolete inventory, leveraging data analysis and lean principles to streamline processes and eliminate waste.
• Coordinate with the Material Planner and Manufacturing team to forecast demand and coordinate inventory accordingly.
• Supervise logistics operations, including transportation, warehousing, and distribution.

Compliance: 20% of TIME

• Ensure compliance with all relevant regulations, standards, and company policies.
• Develop and implement risk management strategies to mitigate supply chain risks.
• Conduct regular audits and assessments to ensure adherence to compliance requirements.
• Perform periodic Supply Chain related document review and logbook reviews.

Personnel Management: 20% of TIME

• Lead, mentor, and develop a team of supply chain professionals, fostering a culture of continuous improvement and high performance.
• Conduct regular performance reviews and provide feedback and coaching to team members.
• Identify training and development needs and implement programs to enhance team skills and capabilities.

QUALIFICATIONS:

Education:

• Bachelor's degree in supply chain or biotech

Experience:

• 8in Supply Chain Operations or related field in Life Science or similar industry with at least 3 years in a management role .
• Strong knowledge of supply chain processes, including procurement, inventory management, logistics, and distribution.
• Requires working knowledge of cGMP, and regulations applicable to the FDA and comparable international regulatory agencies.

Skills:

• Strong organizational and time management skills. Demonstrated ability to work accurately, meet timelines and manage multiple priorities
• Proven track record of implementing process improvements and achieving operational efficiencies.
• Excellent interpersonal, verbal, and written communication skills. Able to work efficiently and effectively collaborating with colleagues and SC vendors.
• Problem solving & adaptability. Strong attention to detail
• Self-driven. Proven ability and desire to learn.
• Able to perform well in a fast-paced and challenging environment.
• Ability to lead and motivate a team, fostering a collaborative and high-performance work environment.
• Basic understanding of logistics management.
• Proficient in Microsoft Applications (Word, Excel, PowerPoint, Projects, etc.)
• Experience in import/export of clinical supplies or knowledge in applicable area.

Base Salary Range: $164,000 - $195,000

Please note that salary varies depending on experience, location, and other factors

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

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