Senior Research Associate I, Lung Biology

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Job description

Who We Are:

ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. ReCode's proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and cells implicated in disease, enabling improved efficacy and potency. ReCode's lead programs include RCT1100 for the treatment of primary ciliary dyskinesia caused by pathogenic mutations in the DNAI1 gene, and RCT2100 for the treatment of the 10-13% of cystic fibrosis patients who have Class I mutations in the CFTR gene and do not respond to currently approved CFTR modulators. RCT1100 and RCT2100 are inhaled disease-modifying mRNA-based therapies formulated using the SORT LNP delivery platform. ReCode is expanding its pipeline to develop potential therapies for other rare and common genetic diseases, including musculoskeletal, central nervous system, liver and infectious disease indications.

Summary of Position:

We are seeking a highly motivated and scientifically rigorous individual to join the Lung-Biology team. This position requires adaptability, strong organizational and communication skills, and the ability to work collaboratively in a dynamic team-oriented environment. A successful candidate will have a background in microscopy and cell biology with a demonstrated ability to integrate into multi-disciplinary project teams to help progress future therapeutics.

Responsibilities:

• Develop cell-based high-content quantitative multiplex IF imaging techniques that can be applied for studying biodistribution pattern of mRNA-LNP.
• Support all imaging-based analysis for our mRNA and gene editing programs.
• Contribute to developing a platform for live cell imaging and quantification for an assay.
• Establish and maintain cell culture for cell-based based assays.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing guidance and troubleshooting where appropriate.
• Contribute to data generation such as technical notes and presentations, in collaboration with cross-functional colleagues.

Qualifications:

• MS in biology or a related field with 5+ years of professional experience. BS in biology or a related field with 7+ years of professional experience. Academic and/or industry experience in the field with a track record demonstrating significant contributions.
• Solid working knowledge and hands-on experience with immunofluorescence (IF) techniques and with different brightfield/fluorescent/confocal microscopes. Experience in developing multiplex fluorescent assays is desirable.
• Hands on cell culture experience is a must.
• Experience with High Content Imaging, analysis software and algorithms for digital image analysis software is a plus.
• Experience with video or time lapse microscopy and analysis a plus.
• Extremely organized and able to efficiently manage time and workflow and day-to-day responsibilities
• Highly collaborative, team-oriented, and considerate of the needs of others
• Desire to work in a fast-paced start-up environment.
• Onsite lab-based position

Salary Range: $94,000 - $100,000

Benefits Offered for Full-Time Employees:

• No premium cost for employees - 100% subsidized by ReCode for full-time employees
• Company 401k contribution
• 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year)
• Mental health support for employees & their families
• FSA available, including a lifestyle spending account subsidized by company
• Employee discounts at hotspots

ReCode Therapeutics () offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.

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