Scientist II, Polysaccharide Analytical Development

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Job description

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

Looking for an energetic and talented individual to join our Polysaccharide Analytical Development team. Primary responsibility for the incumbent will be to provide assay automation with automated and high throughput instruments, method development, and routine assay support to the developmental activities currently on going in the Polysaccharide team as assigned.
Essential Functions:

• Independently design, execute, and interpret routine in-house assays to analyze and characterize polysaccharide intermediates and in-process samples. Assays include:
• Microplate assays, both colorimetric (Ex. Lowry, PicoGreen, etc.) and enzyme-based assays (ELISA/MSD).
• Responsible for the overall quality and compliance of all the testing.
• Responsible for routine instrument maintenance (HPLC, SEC-MAL, GCMS, HPEAC-PAD) and troubleshooting.
• Troubleshoot various issues during analytical method development.
• Complete any assigned tasks and report data in high quality and promptly.
• Provide technical direction, mentorship, and coaching to junior scientists.
• Keep accurate and detailed records of experiments in laboratory notebooks and Benchling entries.
• Summarize data and communicate to cross-functional teams timely and clearly.
• Work within a team environment and provide support to further team objectives.
• Support daily lab operations.

Requirements:

• PhD in Chemistry, Analytical Chemistry, Biochemistry, or related field with 3+ years relevant industry experience; MS with 8+years of industry experience or BS with 12+ years of industry experience in Pharma/ Biotech industry required.
• Must have recent experience in Assay automation with automated and high throughput instruments such as Tecan liquid handlers.
• Experience in chemical/biological/immunological assays such as plate based spectrometric methodology, and ELISA/MSD.
• Ideal candidate will have a background in analytical chemistry principles and hands-on experience with modern analytical instrumentations commonly used in the analysis and characterization of drug candidates.
• Experience in carbohydrate analysis is a plus, for example in HPAEC-PAD, colorimetric methods, HPLC, SEC-MALS, and LC-MS.
• Familiarity with Analytical method development/qualification concepts.
• Attention to detail and excellent skills in record keeping/ documentation.
• Critical thinking and ability to analyze data.
• Strong interpersonal skills; ability to communicate effectively both verbally and in written formats.
• Ability to work under supervision in a fast-paced, cross-functional environment and collaborate effectively with other team members. Eagerness and ability to learn and understand new concepts with ease.

Reports to: Associate Director, Polysaccharide Analytical Development

Location: San Carlos, CA

Compensation:
The compensation package will be competitive and includes an equity component.

Salary Range: $128,000 - $143,000

Vaxcyte, Inc.
825 Industrial Road, Suite 300
San Carlos, CA 94070

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

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