Senior Associate Scientist/Scientist, Immunology

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Job description

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company's Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a motivated, versatile, detail-oriented Senior Associate Scientist / Scientist to join the Immunology Translational Team. The focus will be on preclinical and IND-enabling in vitro studies. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment.

Key Duties and Responsibilities

• Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development
• Work on preclinical and IND-enabling in vitro studies
• Analyze, critically interpret data and share results to project teams as required
• Keep meticulous records of experiments performed and maintain ELN entries
• Work collaborative with other scientists in the group in a highly matrixed lab environment

Education and Experience

• Sr Associate Scientist requires: Bachelor's degree with 6 or more years experience or Master's degree with 2 or more years experience
• Scientist requires: Bachelor's degree with 8 or more years experience or Master's degree with 6 or more years experience
• Experience with molecular/ cell biology techniques such as CRISPR, RT-PCR, cell transfection, cell line generation are required
• Experience using MSD, Luminex and ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required
• Experience developing ex-vivo models to assess immune responses from human whole blood, PBMCs, and various immune cell subsets.
• Experience with cell-based assays including primary cell and reporter cell assays
• Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues is required
• Experience with Western Blots for samples generated from cell pellets and tissue
• Experience with protein quantification techniques from tissue samples
• Experience with tissue explants and organoid systems is a plus

Skills and Abilities

• Independent self-motivated life scientist that can generate scientific questions and design experiments to address them
• Energetic, curious and rigorous
• Excellent problem-solving and organizational skills
• Strong interpersonal and communication skills including presenting data to all levels of the organization
• Scientific rigor and curiosity to address scientific questions and design experiments to test working hypothesis
• Ability to work in fast-paced and matrix environment to meet project goals
• Proficiency in data analysis using Excel, GraphPad Prism, Flow Jo is required

The expected base pay range for this position is $75,000 - $175,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

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