Scientist I/Scientist II, Preclinical Pharmacology

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Job description

Join us in the most challenging and rewarding science of our lives.

Nurix is a science-focused company that is committed to bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating E3 ubiquitin ligases within the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein homeostasis - a function vital to the healthy life of a cell - offering therapeutic opportunities in multiple disease areas. Nurix's scientific team has established an innovative drug discovery platform aimed at identifying novel therapeutics that either modulate ligase function directly or harness it to direct the fate of other disease-relevant target proteins.

Nurix was founded by internationally recognized experts in the UPS field and received its initial funding from leading life science investors, Third Rock Ventures and The Column Group. In 2015, Nurix entered into a multi-year strategic collaboration with Celgene to discover and develop next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology.

Nurix is based in San Francisco's biotechnology hub, Mission Bay - where academia and industry come together for cutting-edge life-saving research.

The Position

We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in oncology, immuno-oncology, and inflammation. The ideal candidate will have expertise in small molecule PK/PD studies, xenograft and syngeneic tumor models, and immune cell profiling by flow cytometry. This role will support novel drug development projects from early lead optimization through clinical candidate selection. Duties include planning, execution and analysis of in vitro and in vivo experiments, management of work within the preclinical pharmacology team, and management of projects at CROs. This individual will work closely with scientists from cross-functional disciplines and present findings to project teams. The candidate must be self-driven, highly organized, and enjoy working in a creative and dynamic team environment.

If you are intrigued by the opportunity to work with a passionate team of scientists focused on improving patient's lives with first-in-class therapies, please consider applying.

Qualifications

• Ph.D. in pharmacology, immunology, cancer biology or a related field. Scientist I requires 1+ years of postdoc or industry experience; Scientist II requires 3+ years of industry experience
• Expertise in oncology, immunology, T cell biology, and in vivo models of disease
• Expertise with flow cytometer-based profiling of immune cells required
• Expertise in small molecule drug development and PK/PD assay technologies
• Expertise with hit-to-lead optimization and establishment of PK/PD relationships
• Management experience of direct reports desired
• Experience as lead representative on project teams desired
• Experience writing preclinical reports for IND filings desired
• Requires excellent communication and presentation skills

To apply, submit your resume to:

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