Senior Research Associate, Oncology Research

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Job description

Senior Research Associate, Oncology Research

About the Company:

Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.

Function:

Oncology Research

Level:

Senior Research Associate

Location:

Foster City, CA

Reporting Manager:

Principal Scientist, Oncology Research

About the Opportunity:

Dren Bio is seeking a highly talented and motivated Senior Research Associate to support our oncology efforts for the treatment of solid tumors. The ideal candidate should have work experience in an industrial setting and have a basic background of immunology and/or cell biology with strong technical experience. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research-stage programs into early clinical development. The candidate will perform in vitro and ex vivo studies to not only assess efficacy of our novel therapeutic agents but to also elucidate their impact on myeloid cell functions within the tumor microenvironment. Importantly, the successful candidate will be provided necessary training, support, and opportunities to grow and to present their work at various project-related meetings.

Role and Responsibilities:

• Perform in vitro/ ex vivo experiments to determine efficacy and MOA of therapeuticantibodies

• Work collaboratively with other researchers to advance various therapeutic antibodiesin different cancer indications

• Specific tasks include recombinant cell line engineering, cell surface receptorquantification by flow, primary and cancer cell culture, isolation of immune cellsfrom human blood, animal or human tissue processing, multi-color flow cytometry forimmuno-phenotyping, cytokine profiling by MSD or Luminex, ADCC or ADCP assays usingIncucyte and flow cytometry, DNA/RNA extraction for gene expression studies, variouscellular assays (IP, western blot, and IF)

• Meticulous record-keeping of scientific data, methods, and study designs

Education, Experience and Qualification Requirements:

• BA/BS or MS in a biology-related discipline with approximately 4+ years of experiencein biopharmaceutical industry, or a combination of 4+ years of industrial andacademic experience

Core Competencies, Knowledge and Skill Requirements:

• Extensive experience in culturing variety of cancer cell lines including lymphoid &myeloid derived cell lines and primary cells

• Experience with flow cytometry-based methods for characterizing cell surfaceexpression

• Transcript/protein quantification assays including qRT-PCR; RNA-seq, ELISA

• Well-versed in various data processing and analysis software (e.g. FlowJo, Prism,ImageJ)

• Detail-oriented, highly organized, and able to multi-task with multiple assignments

• Strong written and verbal communication skills

• Ability to work in a fast-paced environment and the flexibility to align daily workwith project needs

• Ability to set goals and prioritize tasks and resources to achieve superior workquality and efficiency

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company's total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $88,000 and $104,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio's Human Resources department can share more about the specific pay range based on the market location of the candidate.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

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