Grad Intern - Pharmacokinetics and Drug Metabolism (Proteomics focus)

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Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Grad Intern - Pharmacokinetics and Drug Metabolism (Proteomics focus)

What You Will Do

Lets do this. Lets change the world. During this program, you will work within the Pharmacokinetics and Drug Metabolism group at Amgen to develop innovative drug discovery techniques to support programs across multiple therapeutic functions within research and development. Your work will inform drug-target engagement, mechanism of action, and aid in the discovery of novel biomarkers to facilitate drug development. The intern will be responsible for performing cell culture and treatment, sample preparation, reagent screening, LC-MS/MS method development and data analysis. Other responsibilities include electronic laboratory notebook keeping and communication of results to project teams.

The department of PKDM within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The intern will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with fields such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

We are looking for a graduate student with proteomics background. The intern will be working with the team to develop and optimize an untargeted proteomics workflow to identify unknown protein adducts from small molecule drugs and their metabolites, and a targeted LCMS workflow to validate and quantify the adducts. The developed workflows will be implemented into early drug discovery programs with the aim to provide mechanistic insights to support decision-making. The intern will also need to the following:

• Review and summarize project-related literature
• Design and implement project-related experiments
• Analyze, interpret, and present data within PKDM

What We Expect of You

We are all different, yet we all use our unique contributions to serve patients. The motivated individual we seek is a hard worker with these qualifications:

Basic Qualifications:

Amgen requires that all individuals applying for a grad internship or a co-op assignment at Amgen must meet the following criteria:

• 18 years or older
• Graduated with a bachelors degree from an accredited college or university
• Currently enrolled in an MBA program for an MBA internship OR a Masters program for a Masters internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Masters OR Pharm D OR Ph.D. program before the internship starts
• Enrolled in an accredited college or university following the potential internship or co-op assignment
• Must not be employed at the time the internship starts
• Student must be located in the United States for the duration of the internship or co-op

Preferred Qualifications:

• Degree Concentration(s) in analytical chemistry, medicinal chemistry, biochemistry, pharmacology or a related field
• Basic trainings in LCMS
• Basic understanding in enzyme inactivation mechanisms
• Hands on experience in proteomic MS sample preparation technique (biological processing, enzymatic digestion, SPE etc.) and LCMS is preferred
• Highly motivated; enthusiastic about science and problem solving

What You Can Expect of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $30 - $40 per hour.

• Build a network of colleagues that will endure and grow throughout your time with us and beyond.
• Bring your authentic self to the table and become the professional youre inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
• Participate in executive and social networking events, as well as community volunteer projects.

Apply nowfor an internship/co-op that defies imagination

Objects in your future are closer than they appear. Join us.

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Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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