Pharmacokinetics & Drug Metabolism: Senior Scientist Mass Spectrometry and Metabolomics

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Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Pharmacokinetics & Drug Metabolism Mass Spectrometry and Metabolomics - Senior Scientist

What you will do

Lets do this. Lets change the world. In this vital role you will be a part of the department of pharmacokinetics and drug metabolism (PKDM) within Amgen Research. This group is dedicated to the discovery and development of novel, effective, and safe medicines.

The Sr. Scientist will also implement bioanalytical methods for the quantitative and qualitative analysis of various molecular modalities (antibody-drug conjugates, small molecules, lipids, oligonucleotides, peptides, proteins, etc.) in plasma, tissues, and other biological matrices in support of the development of Amgens innovative pipeline.

This role requires an excellent understanding of state-of-the-art bioanalytical techniques and an individual that can work collaboratively in a fast-paced flexible work environment. This position is primarily lab-based, necessitating most of the work to be conducted on site.

Responsibilities

• Develop targeted and un-targeted metabolomics and lipidomics approaches to support biomarker discovery and mechanism of action investigations.

• Employ bioinformatics analysis of complex datasets to interpret and visualize data and effectively communicate results to cross-functional teams.

• Develop and perform quantitative LCMS assays for various molecular modalities.

• Be able to troubleshoot independently when instrument or assay problems arise.

• Other responsibilities will include basic biochemistry research, electronic laboratory notebook keeping and communication of results to project teams.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications:

• Doctorate degree in Biochemistry, Analytical Chemistry, or a related discipline with a background in metabolomics and/or lipidomics research OR

• Masters degree and 3 years of the relevant experience OR

• Bachelors degree and 5 years of the relevant experience

Preferred Qualifications:

• Demonstrated track record of successfully developing or implementing LCMS methods for metabolomics and lipidomics is strongly preferred.

• Experience conducting metabolic flux analysis using stable isotope tracing to probe metabolic pathway activity is desirable.

• Fluency in Python and/or R, as well as the relevant techniques required for statistical analysis, data processing and visualization.

• Hands on experience in sample preparation (biological processing, tissue homogenization, immunoaffinity capture, enzymatic digestion, SPE etc.) and experience with automated platforms (AssayMAP Bravo, Tecan etc.).

• Hands on experience in various HPLC, CE, and Mass Spec instruments is preferred, such as high-flow LC, micro-flow LC, nanoflow LC, QQQ, ToF, Orbitrap, etc.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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