Research Associate II- Antibody Engineering

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Job description

Software Guidance & Assistance, Inc., (SGA), is searching for an Research Associate II Antibody Engineering for a CONTRACT assignment with one of our premier Pharmaceutical Services clients in South San Francisco, CA .

Responsibilities :

Hands-on, lab-based position that requires close collaboration with colleagues in the Antibody Engineering and is in support of various projects across multiple functions in firm Research.

Work with other scientist focused on discovery, developing, and engineering therapeutic antibody candidates.

Apply molecular biology skills to drive the rapid assembly of antibody encoding plasmids for expression from mammalian cells.

Collaborate in developing high throughput plasmid assembly solutions for various complex, and multi-specific antibody designs.

Collaborate with automation engineers to build and develop workflows for high throughput, automated processes for DNA plasmid assembly and clonal mAb selection.

Interact with informatic engineers to develop processes that support automated antibody development workflows including antibody (DNA and protein sequence) registration, tracking, archiving, and inventory.

Required Skills:

B.S. or M.S. degree in molecular biology or related science and 4+ years of applying molecular biology skills, preferably in an antibody research or industrial setting.

Basic understanding of antibody therapeutics including IgGs (variable heavy and light chains and constant region), FAbs, bispecific antibodies, and VHH antibodies).

Experience and expertise in performing polymerase chain reactions (PCR), general DNA plasmid construct assembly, steps necessary for antibody clone isolation including bacterial transformation, bacterial colony picking, bacterial clone culturing, plasmid purification at the mini to maxi scale, and analyzing DNA sequences.

Experience in working with tools for antibody DNA sequence analysis, sequence confirmation, and sequence alignment is essential.

Basic molecular biology skills in DNA ligation, DNA mutagenesis, oligonucleotide design, and endonuclease restriction digestion analysis are also required. Experience with surface plasmon resonance (SPR), performing binding ELISAs and graphing is preferred.

Must have excellent record keeping skills, strong communication skills, and be experienced in data management using Excel or Google Drive.

SGA is a technology and resource solutions provider driven to stand out. We are a women-owned business. Our mission: to solve big IT problems with a more personal, boutique approach. Each year, we match consultants like you to more than 1,000 engagements. When we say let's work better together, we mean it. You'll join a diverse team built on these core values: customer service, employee development, and quality and integrity in everything we do. Be yourself, love what you do and find your passion at work. Please find us at .

SGA is an Equal Opportunity Employer and does not discriminate on the basis of Race, Color, Sex, Sexual Orientation, Gender Identity, Religion, National Origin, Disability, Veteran Status, Age, Marital Status, Pregnancy, Genetic Information, or Other Legally Protected Status. We are committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, and our services, programs, and activities. Please visit our company to request an accommodation or assistance regarding our policy.

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