Scientist/Sr Scientist

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Job description

Overview:
Exagen is a patient-focused and discovery-driven life sciences company dedicated to transforming the care continuum for patients suffering from debilitating and chronic autoimmune diseases. Our goal is to enable rheumatologists to improve care for patients through the differential diagnosis, prognosis, and monitoring of complex autoimmune and autoimmune-related diseases, including lupus and rheumatoid arthritis. By leveraging our proprietary Cell-Bound Complement Activation Products, or CB-CAPs, technology, we help get to the real cause of a patient's symptoms and guide their journey to improved health.

We are seeking a highly skilled PhD-level Toxicologist with expertise in Liquid Chromatography-Mass Spectrometry (LC-MS) to join our laboratory. The successful candidate will lead toxicological studies, design and conduct complex experiments, and analyze a wide range of biological samples. The role requires strong technical proficiency in LC-MS, as well as a deep understanding of toxicology, analytical chemistry, pharmacokinetics, and CLIA validations.

Responsibilities:
LC-MS Method development and Validation-Design, develop, and optimize LC-MS methods for the detection and quantification of small molecules, drugs, metabolites, and toxins in biological matrices

Validate methods in accordance with industry standards and regulatory guidelines

Troubleshoot and maintain LC-MS instruments to ensure consistent and high-quality performance

Sample Analysis and Data InterpretationInterpret complex mass spectrometry data, ensuring accuracy in the identification and quantification of analytes

Collaborate with biostatisticians and bioinformaticians to ensure robust data analysis and reporting

Drive innovation in toxicological testing by integrating new techniques, technologies, and analytical approaches

Demonstrates proficiency, competency & understanding of fundamental principles of clinical laboratory procedures.

Help to investigate complaints, problem, and discrepancy, as needed.

Document all corrective actions are taken when test systems deviate from the laboratory's established performance specifications.

Review/train on new procedures. Identify problems that may adversely affect test performance or reporting of test results, correct the problems encountered, or immediately notify the senior technologist or supervisor.

Resolve routine and non-routine assay problems and ensure the validity of test results through the performance of established quality assurance and quality control procedures.

If applicable, answer questions from customers or other lab personnel.

Appropriately addresses analytical and system performance.

Ability to assist in advanced troubleshooting issues involving LIS, equipment, instruments, and assay performance.

Write and revise existing and new Standard Operating Procedures as needed.

Identifies & resolves unusual laboratory situations & notifies Management.

Provides training, guidance & pertinent technical information to Clinical Laboratory Scientists, Laboratory technicians, Assistants, and support staff.

Discusses clinical laboratory problems of mutual interest with the Management Team to develop a better communication link within the department.

As defined by established standards, works in a professional, cooperative & courteous manner.

Observes all laboratories, Exagen & regulatory agency policies & procedures.

Maintains overall safety (including chemical & biological) of the department under established safety, infection control & procedure protocols.

Qualifications:
PhD in Analytical chemistry, biochemistry, Toxicology, Pharmacology or related field

2-4 years of extensive hands-on experience with LC-MS, including method development, validation, and troubleshooting.

Strong background in toxicology, including experience with TDM (Therapeutic drug monitoring) and toxicity studies

Salary range: $90,000 - $145,000

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