2025 Photostability of Antibody-Drug Conjugates Drug Products Intern

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Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Job Description

Photostability of ADC Drug Products Overview

Envision spending your summer working with energetic colleagues and inspirational leaders, all while gaining world-class experience in one of the most dynamic organizations in the pharmaceutical industry. This is a reality for AbbVie Interns.

Our Biologics Formulation Development team focuses on addressing unique challenges in drug product development. One of such challenges is the photostability of antibody-drug conjugates (ADCs). Certain ADCs exhibit high sensitivity to light due to unique physicochemical properties of the drug-linker as well as the antibody, which may lead to photostability challenges during manufacturing and administration. This internship will provide an opportunity to develop formulation strategies to mitigate light-induced degradation in ADC drug products.

This internship will be based in North Chicago, IL.

Key responsibilities include:

• Design and execute formulation development and predictive stability studies.
• Analytical characterization of formulations using a variety of methods, including but not limited to electrophoresis, liquid chromatography, and mass spectrometry.
• Utilize and improve predictive models for light-induced degradation during manufacturing and administration.
• Utilize in silico modeling to study the interplay of excipient properties and antibody sequence and structure as it relates to light-induced degradation.
• Summarize findings and present them to cross-functional teams and line management.

Qualifications

MinimumQualifications

• Currently enrolled in university, pursuing aPhDin Pharmaceutical Sciences, Biochemistry, Chemistry, Biological Engineering, Chemical Engineering, or other related disciplines with relevant graduate research experience.
• Must be enrolled in university for at least one semester following the internship.
• Strong communication and analytical skills.

Preferred Qualifications

• Expected graduation date between December 2025 - June 2026.
• Hands-on experience with pharmaceutical formulations, protein chemistry and relevant analytical characterization methods.
• Familiarity with the fundamentals of photochemistry and/or in silico modeling tools is a plus.

Benefits and Amenities

• Competitive pay.
• Relocation support for eligible students.
• Select wellness benefits and paid holiday / sick time.
• Opportunity to work with industry-leading professionals.
• Hands-on experience with cutting-edge technologies and methodologies.

Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more or less than the posted range. This range may be modified in the future.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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