Bioanalytical Scientist with Security Clearance

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Job description

REQ#: RQ188430 Public Trust: NACI (T1) Requisition Type: Regular Your Impact Own your opportunity to work alongside federal civilian agencies. Make an impact by providing services that help the government ensure the well being of U.S. citizens. Job Description GDIT is seeking a Bioanalytical Scientist with strong expertise in mass spectrometry to support the Walter Reed Army institute of Research's Experimental Therapeutics Branch. This position will support the research, and any activities needed to most efficiently advance lead candidate drugs to the next level of testing and ultimately FDA approval.In this role, a typical day will include:
Develop and validate analytical methods for the identification of candidate new drugs and putative metabolites using LC-MS/MS instruments including XL LTQ (Thermo Fisher l inear ion trap mass spectrometer and TQ-MS (Waters) tandem quadrupole mass spectrometer. Conduct in vitro and in vivo biological samples analysis using LC-MS/MS instruments, and process and collect raw data from mass spectrometry instruments. Conduct in vitro assays using TeCan Liquid Handling systems and Spectromax plate reader.
Assist with the characterization of metabolites formation and metabolic profiles of candidate drugs using mass spectrometric analysis as needed.
Conduct LC-MS/MS analysis for samples from liver microsomes and hepatocytes extract to assess for potential metabolism-based drug-drug interactions involving hepatic CYP450 enzymes.
Conduct daily and weekly routine maintenance and troubleshoot for HPLC and mass spectrometry systems, a robotic liquid handling system (TeCan Auto sampler), and basic biology and pharmacology laboratory equipment.
Prepare biological samples for analysis using methods to include tissue homogenization, blood spot filter puncture, and solvent extraction as needed.
Conduct ELISA assays in support of pharmacokinetic and biomarker studies as needed.
Perform chemical derivatization reactions when required for analyte detection.
Assist in manual tasks including, but not limited to, filling liquid nitrogen dewars and tanks for use in laboratory operations, biohazard disposal, and acquisition/return of gas tanks from the logistics facility.
Maintain appropriate data records and notebooks.
Assist in chemical and supply inventories and laboratory organization as requested.
Assist with the initiation and tracking of purchase request, and service calls through Medical Maintenance Branch.
Comply with all specified guidelines regarding safety, security, standard operating procedures, written protocols, technical manuals, and procurement of supplies/equipment as per WRAIR regulations.Required:
BS in Analytical Chemistry, Biology, or related field with relevant bioanalytical coursework
2+ years of hands-on experience in analytical chemistry
Working knowledge of HPLC analysis and familiarity with the handling of biological samples.
Experience with Mass Spectrometry
Experience with basic MS Office (or compatible) software for generating reports and summaries for presentations, managing data spreadsheets, requesting supplies and materiel as needed to perform general laboratory maintenance.
Experience with metabolism related studies, along with troubleshooting and basic maintenance of mass spectrometry equipment.
Excellent organizational and interpersonal skills as well as good written and oral communication.
Must be a US citizen with the ability to obtain a favorable NACI T1 security investigation.
Preferred:
MS in Analytical Chemistry, Biology, or related field with relevant bioanalytical coursework with 2+ years of hands-on experience in analytical chemistry
PhD in Pharmaceutical Sciences, Analytical Chemistry, Biology, or related field with relevant bioanalytical coursework with 1+ years of hands-on experience in analytical chemistryWHAT GDIT CAN OFFER YOU:
401K with company match
Customizable health benefits packages
Internal mobility team dedicated to helping you own your career
Challenging work that makes a real impact on the world around you
Full-flex work week Work Requirements Years of Experience 2 + years of related experience may vary based on technical training, certification(s), or degree Certification Travel Required Less than 10% Citizenship U.S. Citizenship Required Salary and Benefit Information The likely salary range for this position is $88,275 - $89,700. This is not, however, a guarantee of compensation or salary. Rather, salary will be set based on experience, geographic location and possibly contractual requirements and could fall outside of this range. View information about benefits and our total rewards program. About Our Work We are GDIT. A global technology and professional services company that delivers consulting, technology and mission services to every major agency across the U.S. government, defense and intelligence community. Our 30,000 experts extract the power of technology to create immediate value and deliver solutions at the edge of innovation. We operate across 30 countries worldwide, offering leading capabilities in digital modernization, AI/ML, Cloud, Cyber and application development. Together with our clients, we strive to create a safer, smarter world by harnessing the power of deep expertise and advanced technology. GDIT is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or veteran status, or any other protected class.

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