Scientist - In Vivo Pharmacology

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Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

Organization Overview:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

We serve an extraordinary purpose. For more than 140 years, we have worked diligently to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world's greatest health challenges.

At the Lilly Innovation Center in Boston, Massachusetts, we explore how next generation therapeutics, new technologies, data analytics and new care models can improve patient health and the healthcare system. Our Genetic Medicine team in Boston shares a passion for challenging conventional wisdom and creating an environment that embraces creative, break-through concepts. The Center offers a start-up environment with large company support. It is located in the heart of Massachusetts' exploding science and technology cluster and is within walking distance of some of the best academic and industry innovators in the world.

The successful candidate will have a strong research track record in biology and be analytically minded, systematic, and embrace data-driven decision making. The scientist will collaborate with multidisciplinary teams across key Lilly therapeutic areas (e.g. neuroscience, diabetes, immunology) to perform experiments to aid development of RNA oligonucleotide drug candidates for the next generation of RNA therapies.

Key responsibilities include:

• Work with project team leads to design and plan in vivo experiments to support the preclinical characterization and evaluation of novel therapeutic molecules.
• Perform rodent handling and dosing, including but not limited to subcutaneous (SC), intravenous (IV), intraperitoneal (IP) and intrathecal (IT) injections.
• Perform small animal stereotaxic surgeries including but not limited to intracerebral (IC), intracisterna magna (ICM) and intracerebroventricular (ICV) injections in rodents.
• Perform tissue dissection, trimming and processing, collect bodily fluids (blood, cerebrospinal fluid).
• Process tissue samples for gene expression or protein endpoints
• Support technology development for improving the delivery of novel therapeutics to regions of interest in the central nervous system or other tissues.
• Assist in troubleshooting technical challenges and provide scientific and technical input to project teams
• Help design and complete experiments and perform data analysis
• Provide written and verbal communication of work in lab reports and team meetings
• Accurate recording of all practical work: completion of electronic notebook to Lilly procedure quality standards
• General laboratory assistance, including ordering and receiving lab supplies, preparation of reagents, and maintain laboratory equipment
• Ensure compliance with all health and safety regulations
• Passionate about contributing in the lab in a diverse and inclusive environment every day

Basic Qualifications:

• Bachelors or Masters degree in biology, biochemistry, pharmacology, or related scientific field.
• 1+ years of work experience in the pharmaceutical industry, an academic laboratory, or similar settings

Additional Skills/Preferences :

• Experience in developing and working with in vivo models and assays to support drug discovery programs.
• Hands-on competencies in designing and executing in vivo pharmacological experiments.
• Knowledge and understanding of drug delivery concepts is preferred.
• Strong expertise with in vivo tissue dissection and processing.
• Experience in gene expression assays (e.g. qPCR) or protein assays (e.g. Western blot or ELISA)
• Ability to adapt and exercise flexibility for changing platform needs, workflows and projects.
• Excellent communication skills and efficiency in collaborating across functional boundaries and in team environment
• Strong organization skills, attention to detail, critical thinking, multitasking, desire to learn new techniques and contribute to innovative projects in a fast-paced working environment
• Excellent interpersonal skills
• Experience in processing, organizing, analyzing and visualizing data and information from disparate sources and ability to extract insight from data
• Familiar with Excel, Word, PowerPoint, and analytical software associated with methods.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women's Network, Working and Living with Disabilities. Learn more about all of our groups.

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