Principal Scientist I, Precision Medicine Translational Research Immunology

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Job description

Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Job Description
We are seeking a highly motivated and creative Scientist with a scientific background in immunology or immuno-oncology to join Precision Medicine Translational Research Immunology Group as Principal Scientist at AbbVie. The candidate will provide leadership in clinical biomarker strategy and assay development in inflammatory/autoimmune disease areas, including Dermatology, Gastroenterology, Rheumatology and Fibrosis for AbbVies drug development programs from late discovery to clinical trials. The successful candidate will be part of a growing translational research group working with cross-disciplinary teams both internally and externally.

Key Responsibilities:

• Lead biomarker strategies through cross-functional teams in a matrix environment to identify gaps and develop fit-for-purpose clinical TE/PD biomarker, predictive and exploratory biomarker assays to support human dose projection and establish early signs of efficacy in clinical trials and patient selection strategies.
• Collaborate with Data Science team and Precision Medicine lead to analyze internal and external omics data, understand heterogeneity of diseases, identify disease endotypes, support disease strategy and generate patient selection and combination hypotheses for further testing with preclinical studies.
• Develop preclinical patient derived disease models, design studies with appropriate controls and endpoints tounderstand drug targetmechanismsfor PD biomarker development and evaluate biomarker hypotheses and combination strategies.
• Serve as a subject matter expertise in analytical methodologies/technologies for translational research including single cell and spatial omics, proteomics, methylomics, metabolomics, genomics, NGS, MSD, ELISA, Luminex, flow cytometry, ex vivo primary cell culture and organoid-immune cell culture.
• Manage external CROs and academic collaborations including study proposal, budget, timeline, and data review.
• Manage and coach a team of translational scientists, ensuring the successful execution of translational research plans across multiple projects.
• Keep abreast of latest research & development in inflammatory and immune diseases through critically reviewing literature, attending conferences, and seeking advice from KOLs.

Qualifications
Qualifications:

• Major or advanced degree in Immunology, cell & molecular biology, pharmacology, pathology, bioinformatics or other relevant biological sciences. B.S. & typically 14+ years, M.S. & typically 12+ years, Ph.D., or equivalent & typically 8+ years of relevant industrial biotechnology experience.
• Experience in leading translational medicine in Rheumatological diseases (RA, SLE, SSc) is a plus.
• Expertise in a broad range of translational technologies, data analytics and computational tools.
• Proficient in multi-parameter flow cytometry, including spectral flow cytometry and analytical software (e.g., BD FACSDiva, Flowjo, OMIQ) to analyze different immune cell types and cell states from mice, human and cynomolgus monkey.
• Experienced in designing and conducting single cell omics, spatial omics, genomic-based assays and developing analytical workflow to generate or validate biomarker hypotheses.
• Knowledgeable with integrative analysis of multi-dimensional datasets using bioinformatics tools and methods (e.g., R, Python, SQL, AI/ML, HPC and cloud environments)
• Strong project leadership and organizational skills to prioritize tasks and allocate resources to meet projects goals in a tight timeline.
• Experienced in managing CROs and collaborators, facilitating meetings, and working independently and collaboratively with multi-functional teams in a dynamic and fast paced environment.
• Demonstrated ability to supervise and coach direct reports.
• Excellent communication, presentation, organizational and people management skills
• Strong track-record of scientific publications from peer reviewed journals and presentations in major conferences

Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible to participate in our short-term incentiveprograms.
• This job is eligible to participate in our long-term incentiveprograms

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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