Research Scientist II, Gene Editing (Durham NC)

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Job description

Who We Are:

ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. ReCode's proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and cells implicated in disease, enabling improved efficacy and potency. ReCode's lead programs include RCT1100 for the treatment of primary ciliary dyskinesia caused by pathogenic mutations in the DNAI1 gene, and RCT2100 for the treatment of the 10-13% of cystic fibrosis patients who have Class I mutations in the CFTR gene and do not respond to currently approved CFTR modulators. RCT1100 and RCT2100 are inhaled disease-modifying mRNA-based therapies formulated using the SORT LNP delivery platform. ReCode is expanding its pipeline to develop potential therapies for other rare and common genetic diseases, including musculoskeletal, central nervous system, liver and infectious disease indications.

Summary of Position:

We are seeking skilled and motivated gene editing scientist to join our Durham, NC location, dedicated to gene correction drug development targeting rare diseases of the lung. You will be involved in applying advanced gene editing technologies to support ReCode's gene correction programs and delivery discovery platform function. This position requires adaptability, strong organizational and communication skills, and the ability to work collaboratively in a dynamic team-oriented environment.

You will work closely with a team of cell and molecular biologists working in both in vitro and in vivo models of lung disease. This is a unique opportunity to be part of a fast-paced, rapidly growing company developing a pipeline of therapies for severe life-limiting diseases.

Responsibilities:

• Lead, design, and execute experiments using next-generation gene editing and epigenome editing strategies with CRISPR-based tools and beyond.
• Advance gene correction applications for therapeutic and non-viral platform discovery projects through the design, implementation/optimization, and execution of molecular biology, cell biology, and NGS-based assays.
• Support the discovery of novel LNP delivery solutions through in vitro and in vivo gene editing screens.
• Work with primary in vitro cell culture disease models of lung epithelial cells.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
• Analyze and present experimental data to a wide range of audiences.
• Trouble shoot and dissect published literature to find novel solutions to resolve technical and/or biological hurdles.
• Contribute as a key member of a cross functional drug discovery team that includes gene correction, primary human biology, pharmacology, computational biology, bioanalytical, toxicology and formulation capabilities.
• Prepare SOPs, keep excellent electronic lab notebook and record keeping entries, and prepare reports and/or manuscripts for publication.
• Manage one or more direct reports; mentor additions to the team.

Qualifications:

• PhD in molecular biology, cell biology, biological engineering or related discipline with 4 years of experience in postdoctoral research and/or industry.
• Subject matter expertise, with a proven track record of publications/patents, in gene editing, with a broad knowledge of gene editing applications.
• Hands-on experience using gene editing tools including next generation CRISPR systems (e.g. Prime or Base editors)
• Deep expertise in analytic RNA or DNA assays to measure an analyze gene editing results.
• Experience in utilizing bioinformatics tools and software for the analysis of gene editing readouts
• Experience in mammalian cell and tissue culturing is required.
• Experience with viral or non-viral delivery platforms, preferably lipid nanoparticles (LNPs) (recommended)
• Understanding of lung biology and/or rare lung disease (recommended)
• Excellent verbal and written communication skills, with proven ability to write reports and/or articles for publication.
• Advanced knowledge of statistical and genome analytical tools (GraphPad, R, SnapGene)
• Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization.
• Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities.
• Highly collaborative, team-oriented, and considerate of the needs of others.
• Desire to work in a fast-paced environment and contribute to developing the next generation of gene editing.

Position is based in Durham, role provides relocation for candidates not living in Durham

Salary Range:

120-130k- Please note that for remote positions, salary may be adjusted for cost of living

Benefits Offered for Full-Time Employees:

• No premium cost for employees - 100% subsidized by ReCode for full-time employees
• Company 401k contribution
• 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year)
• Mental health support for employees & their families
• FSA available, including a lifestyle spending account subsidized by company
• Employee discounts at hotspots

ReCode Therapeutics () offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.

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