Scientist- High Throughput Screening (Automation) (Seattle, WA)

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Job description

We are seeking a highly motivated Scientist to join our Research team within Regeneron Cell Medicine. You will help support our automation pipeline to drive medium to high throughput CAR-T and TCR binder triage and binder optimization experiments forward. We hope you are excited by the opportunity to help advance the next generation of cell therapies.

As a Scientist, a typical day might include:

• Using Hamilton Vantage liquid handlers to drive medium to small scale T-Cell expansions

• Designing and cloning CAR/TCR constructs into lentiviral vectors

• Generating LVV in a high throughput manner to drive binder triage experiment

• Engineering T cells with CARs or TCRs using lentiviral vectors

• Performing in-vitro immunological assays such as T-Cell cocultures, cytotoxicity, and immunophenotyping by flow cytometry

• Assisting in the development of an improved TCR based off target derisking platform utilizing cell-based assays

• Setting up and performing in depth characterization of binders utilizing a variety of methods

• Culturing and maintaining tumor cell lines, including the production and engineering of overexpression and knockout cell lines

• Compiling, tracking, and visualizing multiple readouts from various immunological assays for presentations and to drive data-based decision making

This role may be for you if you:

• Have hands on experience troubleshooting and maintaining various automated instruments

• Have strong communication and organizational skills and easily adapt to a rapidly changing fast-paced team environment.

• Have strong commitment to continuing to learn new skills/techniques

• Have the desire to integrate and function in a team-based environment

• Are independently motivated and have excellent attention to detail

In order to be considered for this role, you must have a B.S or M.S. in Science/Engineering or related field with 6+ years of relevant experience. Must have experience working with automated liquid handlers (Hamilton, Tecan, etc.). Experience with Python or R is preferred. Knowledge of Hamilton GUI guided workflow language is advantageous. Must have experience with cell culture. Experience with protein-based techniques such as Biacore is preferred.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)

$90,700.00 - $148,100.00

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