Research Associate/Senior Research Associate: Protein and Cell Biology

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Job description

Research Associate/Senior Research Associate: Protein and Cell Biology

About the Company:

Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.

Function:

Biologics Discovery

Level:

Associate/ Senior Associate

Location:

Foster City, CA

Reporting Manager:

Senior Scientist II, Biologics Discovery

About the Opportunity:

We are seeking an energetic, self-motivated, collaborative Research Associate II / Senior Research Associate to join our Biologics research group dedicated to the discovery and development of novel oncology therapeutics. The position initially will primarily support cell biology with occasional support of protein engineering, production, and analytic functions as needed. This is an exciting opportunity contribute to the foundational science and culture of a biotech start-up backed by an experienced team. The ideal candidate will have significant experience in one or more areas of responsibility listed below, the willingness and drive to learn new technical skills, solid critical thinking and troubleshooting skills and the desire to witness and drive the growth of a new company from the ground up. Title, compensation and scope of duties will be tailored to the successful candidate's experience.

Role and Responsibilities:

• Protein production of antibodies and bispecifics using transiently expressing celllines (experience with Expi293 and AKTA machines is appreciated).

• Design and execution of in vitro biochemical and cell-based assays characterizingearly stage bispecific antibody drug therapeutic candidates

• Work independently and collaboratively in a small team environment

• Mammalian cancer cell line cataloging and maintenance

• Laboratory equipment sourcing and maintenance

• Transfection & production of antibodies and other proteins from mammalian cells

• Protein purification by chromatography - affinity, IEX, SEC.

• Protein characterization (affinity determination, competitive binding assays, epitopedetermination) by BLI

Education, Experience and Qualification Requirements:

• BS in cell biology, Immunology, molecular biology or related science with 4+ years orMSc with 2+ years of relevant industry experience.

Core Competencies, Knowledge and Skill Requirements:

• Experience with transient mammalian (CHO and HEK) antibody or other proteinexpression a plus.

• Experience with protein purification and QC (AKTA, SDS-PAGE, SEC, endotoxin assays) aplus.

• Experience with protein characterization using BLI and/or SPR

• Excellent documentation, organizational skills and teamwork/communication skills arerequired.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company's total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $78,000 and $104,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio's Human Resources department can share more about the specific pay range based on the market location of the candidate.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

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